Your doctor can choose from several dozen possible medications and/or a combination of medications to treat your high blood pressure.
Diuretics help the kidneys eliminate sodium and water from the body. This process decreases blood volume, so your heart has less to pump with each beat, which in turn lowers blood pressure. Among the most popular are:
- Chlorthalidone (Hygroton)
- Hydrochlorothiazide (Hydrodiuril, Microzide, Esidrix)
- Indapamide (Lozol)
- Metolazone (Mykrox, Zaroxolyn).
Side effects of diuretics include:
- Frequent urination
- Arrhythmia (irregular heartbeat)
- Weakness
- Muscle cramps
- Dehydration
- Dizziness/confusion
- Nausea/loss of appetite
Anti-adrenergics lower blood pressure by limiting the action of the hormones epinephrine and norepinephrine, thereby relaxing the blood vessels and reducing the speed and force of the heart’s contractions. This class of medicines includes:
- Guanadrel (Hylorel)
- Guanethidine monosulfate (Ismelin)
- Reserpine (Serpasil)
- Clonidine hydrochloride (Catapres)
- Guanabenz acetate (Wytensin)
- Guanfacine hydrochloride (Tenex)
- Methyldopa (Aldomet).
Side effects of anti-adrenergics include:
- Drowsiness
- Vomiting/Nausea
- Headache
- Muscle weakness
- Diarrhea
- Dry mouth
- Impotence
- Irregular heartbeat
Direct-acting vasodilators relax the arteries. They act quickly and are often used in emergencies. Vasodilators include:
- Hydralazine hydrochloride (Apresoline)
- Minoxidil (Loniten).
Side effects of direct-acting vasodilators include:
- Dizziness
- Headache
- Anxiety
- Mild Rash
- Muscle or Joint pain
- Nausea/vomiting
- Diarrhea/constipation
- Fast heartbeat
- Flu-like symptoms
- Swelling in the hands, ankles, or feet
Calcium channel blockers slow the movement of calcium into the smooth-muscle cells of the heart and blood vessels. This weakens heart muscle contractions and dilates blood vessels, lowering blood pressure. Some calcium channel blockers include:
- Amlodipine (Norvasc)
- Diltiazem (Tiazac)
- Felodipine (Plendil)
- Isradipine (DynaCirc)
- Nicardipine (Cardene SR)
- Nifedipine (Adalat, Procardia)
- Nisoldipine (Sular)
- Verapamil (Calan, Verelan, Covera-HS)
Side effects of calcium channel blockers include:
- Constipation
- Nausea
- Headache
- Rash
- Edema (swelling of the legs with fluid)
- Low blood pressure
- Drowsiness
- Dizziness
- Liver disease
ACE (Angiotensin-converting enzyme) inhibitors lower your blood pressure by inhibiting the formation of angiotensin, which causes blood vessels constriction and increases blood pressure. . Some ACE inhibitors are:
- Benazepril hydrochloride (Lotensin)
- Captopril (Capoten)
- Enalapril maleate (Vasotec)
- Fosinopril sodium (Monopril)
- Lisinopril ( Prinivil, Zestril)
- Moexpiril (Univasc)
- Quinapril hydrochloride (Accupril)
- Ramipril (Altace)
- Trandolapril (Mavik).
Side effects of ACE inhibitors include:
- Cough
- Elevated blood potassium levels
- Weakness
- Drowsiness
- Rash
- Headache
- Low blood pressure
Angiotensin-receptor blockers (ARBs) blocks angiotensin II, a substance in the body, from constricting the blood vessels and stimulating salt and water retention. They include:
- Azilsartan (Edarbi)
- Candesartan (Atacand)
- Eprosartan (Teveten)
- Irbesartan (Avapro)
- Losartan (Cozaar)
- Olmesartan (Benicar)
- Telmisartan (Micardis)
- Valsaartan (Diovan)
Side effects of ARBs include:
- Dizziness
- Insomnia
- Vomiting/Diarrhea
- Muscle cramps
- Dehydration
- Irregular heartbeat
- Upper respiratory tract infection
Direct renin inhibitors, which block the action of angiotensin II. They represent a newer generation of blood pressure medications. Renin inhibitors work by inhibiting the activity of renin, the enzyme largely responsible for angiotensin II levels.
Side effects of direct renin inhibitors include:
- Dizziness
- Headaches
- Diarrhea
- Stuffy nose
- Back pain
- Joint swelling